Adult Max daily dose: 20 mg. Achieve maintenance dose by upward titration of 5 mg/wk over 1st 3 wk. Wk 1 (day 1-7): 5 mg daily for 7 days. Wk 2 (day 8-14): 10 mg daily for 7 days. Wk 3 (day 15-21): 15 mg daily for 7 days. From Wk 4 on: 20 mg daily. Maintenance dose: 20 mg daily.
Elderly >65 yr 20 mg daily.
Moderate renal impairment (CrCl 30-49 mL/min) 10 mg daily if tolerated well after at least 7 days, may increase up to 20 mg daily.
Severe renal impairment (CrCl 5-29 mL/min) 10 mg daily.