IV 1 mg on cycle 1 day 1 as infusion over a min of 4 hr. 2 mg on cycle 1 day 8 as infusion over a min of 4 hr. 60 mg on cycle 1 day 15 as infusion over a min of 4 hr. 60 mg on cycle 2 day 1, may administer over 2 hr if infusions were well-tolerated in cycle 1. 30 mg on cycle 3+ day 1, may administer over 2 hr if infusions were well-tolerated in cycle 1. Duration of treatment: 8 cycles; additional 9 cycles should be administered if w/ partial response or have stable disease in response to treatment after 8 cycles unless unacceptable toxicity or disease progression occurs.