1st-line treatment in patients w/ locally advanced or metastatic NSCLC w/ EGFR activating mutations. Switch maintenance treatment in patients w/ locally advanced or metastatic NSCLC w/ EGFR activating mutations & stable disease after 1st-line chemotherapy. Patients w/ locally advanced or metastatic NSCLC after failure of at least one prior chemotherapy regimen. In combination w/ gemcitabine for 1st-line treatment in patients w/ locally advanced, unresectable or metastatic pancreatic cancer.