1st-line treatment in postmenopausal women w/ advanced hormone-dependent breast cancer. Advance breast cancer in women w/ natural or artificially induced postmenopausal status, who have previously been treated w/ antioestrogens. Adjuvant treatment of postmenopausal women w/ hormone receptor +ve invasive early breast cancer. Extended adjuvant treatment of early breast cancer in postmenopausal women who have received prior standard adjuvant tamoxifen therapy.