IV Individualized dosage based on severity of factor VIII deficiency, location & extent of bleeding & patient's clinical condition.
Early haemarthrosis, muscle or oral bleeding (20-40%) 12-24 hrly for at least 1 day until bleeding episode is resolved or healing is achieved.
More extensive haemarthrosis, muscle bleeding or haematoma (30-60%) 12-24 hrly infusion for 3-4 days or more until pain & acute disability are resolved.
Life-threatening haemorrhages (60-100%) 8-24 hrly infusion until threat is resolved.
Minor surgery including tooth extraction (30-60%) 24 hrly for at least 1 day until healing is achieved.
Major surgery (80-100% pre- & postop) 8-24 hrly until adequate wound healing, then repeat therapy for at least 7 days to maintain 30-60% factor VIII activity.
Long-term bleeding prophylaxis Patient w/ severe haemophilia A 20-40 IU/kg at 2-3 days intervals.