Adult 1 mg bd following a 1-wk titration as: 0.5 mg once daily on days 1-3, 0.5 mg bd on days 4-7 & 1 mg bd on day 8 until the end of treatment. Treatment duration: 12 wk. Start dosing 1 wk before quit date. Alternatively, patient can begin dosing & then quit smoking between days 8 & 35 of treatment.
Patient who has successfully stopped smoking at the end of 12 wk Maintenance of abstinence: Additional 12-wk treatment course w/ 1 mg bd.
Patient who is unable or willing to quit abruptly Reduce smoking during the 1st 12 wk of treatment & quit by the end of treatment period; continue treatment for an additional 12 wk for a total of 24 wk of treatment.
Severe renal impairment Initially 0.5 mg once daily for 1st 3 days then increased to 1 mg once daily.