Caduet

Patients for whom treatment w/ both amlodipine & atorvastatin is appropriate. Amlodipine: 1st-line treatment of HTN; symptomatic treatment of chronic stable angina; confirmed or suspected vasospastic angina; to reduce the risk of hospitalization (due to angina) & coronary revascularization procedure in angiographically documented CAD. Atorvastatin: Adjunct to diet for reduction of elevated total cholesterol (total-C), LDL-C, apo B & triglycerides (TG) in patients w/ primary hypercholesterolemia, heterozygous familial hypercholesterolemia (FH) or combined (mixed) hyperlipidemia (Fredrickson types IIa & IIb), elevated serum TG levels (Fredrickson type IV) & in patients w/ dysbetalipoproteinemia (Fredrickson type III) when response to diet & other non-pharmacological measures is inadequate; to diet & other non-dietary measures in reducing elevated total-C, LDL-C & apo B in patients w/ homozygous FH. Raises HDL-C & lowers the LDL/HDL & total-C/HDL ratios. Prevention of CV disease (reduces risk of MI in adult hypersensitive patients w/o clinically evident CHD; risk of MI & stroke in patients w/ type 2 diabetes & w/o clinically evident CHD but w/ multiple risk factors for CHD; risk of non-fatal MI, fatal & non-fatal stroke, revascularization procedures, hospitalization for CHF & angina in patients w/ clinically evident CHD).

Individualized starting & maintenance dose. Dosage range: 5/10 mg to a max dose of 10/80 mg once daily. Combination therapy max atorvastatin dose: 10 mg (w/ cyclosporine, telaprevir, or tipranavir/ritonavir); 20 mg (w/ elbasvir/grazoprevir).

May be taken with or without food.

Hypersensitivity to dihydropyridines, amlodipine or atorvastatin. Concomitant treatment w/ glecaprevir/pibrentasvir. Active liver disease or unexplained persistent elevations of serum transaminases >3x ULN. Women of childbearing potential who are not using adequate contraceptive measures. Pregnancy & lactation.

Calcium Antagonists / Dyslipidaemic Agents / Anti-Anginal Drugs

C10BX03 - atorvastatin and amlodipine ; Belongs to the class of HMG CoA reductase inhibitors, other combinations.

POM