Hypersensitivity. Severe immunodeficiency states (eg, AIDS). Patients w/ significantly impaired bone marrow function or significant anaemia, leucopenia, neutropenia or thrombocytopenia due to causes other than rheumatoid or psoriatic arthritis; serious infections; severe hypoproteinaemia (eg, nephrotic syndrome). Moderate to severe renal impairment. Liver impairment. Women of childbearing potential who are not using reliable contraception during treatment. Pregnancy & lactation.