Avelox Dosage & Drug Information

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Core Prescribing Info

Contents

Moxifloxacin HCl

Indications/Uses

Community-acquired pneumonia caused by Strep pneumoniae, H. influenzae, Mycoplasma pneumoniae, Chlamydia pneumoniae or Moraxella catarrhalis. Complicated skin & skin structure infections caused by methicillin-susceptible Staph aureus, E. coli, Klebsiella pneumoniae, Enterobacter cloacae. FC tab: Acute bacterial sinusitis caused by Strep pneumoniae, H. influenzae or Moraxella catarrhalis. Acute bacterial exacerbation of chronic bronchitis caused by Strep pneumoniae, H. influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Staph aureus or Moraxella catarrhalis. Uncomplicated skin & skin structure infections caused by Staph aureus or Strep pyogenes. Mild to moderate pelvic inflammatory disease w/o associated tubo-ovarian or pelvic abscess.

Dosage/Direction for Use

Adult FC tab 400 mg once daily. Duration of treatment: Acute exacerbation of chronic bronchitis 5 days. Acute sinusitis & uncomplicated skin & skin structure infections 7 days. Community-acquired pneumonia (mild to moderate) 10 days. Mild to moderate pelvic inflammatory disease 14 days. Soln for infusion IV 400 mg infused over 60 min. Duration of treatment: Community-acquired pneumonia (IV-to-PO sequential therapy) 7-14 days. Complicated skin & skin structure infections (IV-to-PO sequential therapy) 7-21 days.

Administration

FC tab: May be taken with or without food: Swallow whole w/ sufficient liqd.

Contraindications

Hypersensitivity to moxifloxacin or other quinolones. History of tendon disease/disorder related to quinolone treatment. Congenital or documented acquired QT prolongation. Electrolyte disturbances particularly in uncorrected hypokalaemia. Clinically relevant bradycardia & heart failure w/ reduced left-ventricular ejection fraction. History of symptomatic arrhythmias. Concurrent use w/ drugs that prolong QT interval. Hepatic impairment (Child-Pugh C) & patients w/ transaminase increase >5 fold ULN. Pregnancy & lactation. Patients <18 yr.

MIMS Class

Quinolones

ATC Classification

J01MA14 - moxifloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.

Regulatory Classification

POM

Presentation/Packing

Form

Avelox FC tab 400 mg

Packing/Price

1's

Form

Avelox soln for infusion 400 mg/250 mL

Packing/Price

1's

Avelox

moxifloxacin

Manufacturer:

Bayer AG