Tocopheryl nicotinate

Nausea, diarrhoea, constipation, stomach ache/discomfort, anorexia, rash, flushing, oedema, and liver dysfunction (elevated AST, ALT).

Higher absorption when administered after a meal.

Description:
Mechanism of Action: Tocopheryl nicotinate is the esterified compound of tocopherol and nicotinic acid which has more potent pharmacological activity than a dose of both drugs given concurrently. Tocopheryl nicotinate is a lipid regulating drug which can reduce total serum cholesterol and triglycerides, and increase HDL cholesterol. It has also been shown to enhance microcirculation, inhibit platelet aggregation, prevent capillary fragility, and restore arterial oxygen partial pressure.
Pharmacokinetics:
Absorption: Following a single oral admin of 600 mg dose, Tmax of Tocopheryl nicotinate (unchanged form): About 6 hr; tocopherol (hydrolysed form): About 10 hr.
Excretion: Elimination half-life of Tocopheryl nicotinate: About 4.3 hr; tocopherol (hydrolysed form): About 38.5 hr.

Store at room temperature. Protect from heat and moisture.

Dyslipidaemic Agents / Peripheral Vasodilators & Cerebral Activators