Discontinue use if seizures or increased seizure frequency, jaundice or serotonin syndrome occurs; in patients entering manic phase. Monitor clinical worsening, suicidal behavior or thoughts, unusual behavior changes. History of suicide-related events or exhibiting significant degree of suicidal ideation; mania/hypomania. Bone marrow depression; cardiac disease eg, conduction disturbances, angina pectoris & recent MI; low BP, DM; schizophrenia or other psychotic disturbances; bipolar disorder; micturition disturbances eg, prostrate hypertrophy, acute narrow-angle glaucoma, increased IOP; akathisia/psychomotor restlessness; hyponatremia. Patients w/ known CV disease & history of QT prolongation. Phenylketonuria due to aspartame. Not to be taken by patients w/ fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency. Concomitant use w/ drugs prolonging QTc interval & causing hyponatremia; SSRIs. Avoid abrupt w/drawal. May affect ability to drive & use machines. Hepatic & renal impairment. Pregnancy & lactation. Not to be used in childn & adolescent <18 yr. Elderly.
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