Carbachol: Uses, Dosage, Side Effects and More

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Intraocular
Miosis during surgery, Reduction of postoperative rises in intraocular pressure

Adult: As 0.01% solution: Instil 0.5 mL into the anterior chamber before or after securing sutures. Do not administer more than 0.5 mL into the anterior chamber. Refer to specific product guidelines for detailed instructions on dose preparation.

What are the brands available for Carbachol in Malaysia?

Miostat

Special Precautions

Patient with asthma, acute heart failure, peptic ulcer, gastrointestinal spasm, hyperthyroidism, urinary tract obstruction, Parkinson's disease. Pregnancy and lactation.

Adverse Reactions

Significant: May increase surgically induced intraocular inflammation.
Eye disorders: Corneal clouding, persistent bullous keratopathy, retinal detachment; postoperative iritis (following cataract extraction).
Gastrointestinal disorders: Epigastric distress, abdominal cramps, vomiting.
Nervous system disorders: Headache.
Renal and urinary disorders: Bladder spasm.
Skin and subcutaneous tissue disorders: Sweating.
Vascular disorders: Flushing.

Pregnancy Category (US FDA)

Intraocular/Ophth: C

Patient Counseling Information

This drug may cause temporary blurring of vision, if affected, do not drive or operate machinery.

Overdosage

Symptoms: Headache, vomiting, abdominal cramps, salivation, diarrhoea, asthma, syncope, bradycardia, and hypotension. Management: Supportive treatment. For severe systemic toxicity, anticholinergics may be given.

Action

Description:
Mechanism of Action: Carbachol, a choline ester, is a direct-acting parasympathomimetic agent. It stimulates the muscarinic receptors in the eye, causing constriction of the iris and ciliary body, leading to a reduction in intraocular pressure.
Onset: Miosis: Within 2-5 minutes.
Duration: Miosis: Approx 24 hours.

Chemical Structure

Storage

Store between 15-30°C. Do not freeze or refrigerate.

MIMS Class

Miotic Drugs

ATC Classification

S01EB02 - carbachol ; Belongs to the class of parasympathomimetics. Used in the treatment of glaucoma and miosis.

References

Alcon Laboratories (New Zealand) Limited. Miostat Intraocular Injection 150 mcg/1.5 mL data sheet 17 August 2020. Medsafe. http://www.medsafe.govt.nz. Accessed 02/07/2025.

Brayfield A, Cadart C (eds). Carbachol. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/07/2025.

Carbachol. UpToDate Lexidrug, AHFS DI (Adult and Pediatric) Online. American Society of Health-System Pharmacists, Inc. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 02/07/2025.

Carbachol. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 02/07/2025.

Miostat Intraocular Solution 0.01% (Alcon Laboratories [Malaysia] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 02/07/2025.

Miostat Solution (Alcon Laboratories, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 02/07/2025.

Disclaimer: This information is independently developed by MIMS based on Carbachol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2025 MIMS. All rights reserved. Powered by MIMS.com