Amcinonide: Uses, Dosage, Side Effects and More

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Corticosteroid-responsive dermatoses

Adult: For relief of inflammatory and pruritic manifestations: As 0.1% cream or ointment: Apply a thin film to the affected area(s) 2-3 times daily, depending on the severity of the condition.
Child: Treatment recommendations may vary among countries and between individual products (refer to specific product guidelines).

Special Precautions

Avoid use of occlusive dressings in the presence of infected or weeping lesions. Children. Pregnancy and lactation.

Adverse Reactions

Significant: HPA axis suppression or hypercortisolism (particularly in younger children or in patients receiving high doses for prolonged periods); allergic contact dermatitis; Kaposi's sarcoma (prolonged use); systemic effects (e.g. Cushing's syndrome, hyperglycaemia, glycosuria).
Skin and subcutaneous tissue disorders: Skin irritation (including burning), itching, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, skin maceration, skin atrophy, striae, miliaria.

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

Avoid contact with the eyes. Do not use with occlusive dressings unless directed by the doctor.

Action

Description:
Mechanism of Action: Amcinonide is a highly potent topical corticosteroid that has anti-inflammatory, antipruritic, and vasoconstrictive properties. It may suppress the formation, release, and activity of endogenous inflammatory chemical mediators (e.g. kinins, histamine, liposomal enzymes, prostaglandins) via induction of phospholipase A₂ inhibitory proteins (lipocortins) and subsequent inhibition of the release of arachidonic acid.
Pharmacokinetics:
Absorption: Adequately absorbed through intact skin; increased absorption with skin inflammation or use of occlusive dressings.
Metabolism: Metabolised in the liver.
Excretion: Via urine and faeces.

Chemical Structure

Storage

Store between 20-25°C. Do not freeze.

MIMS Class

Topical Corticosteroids

ATC Classification

D07AC11 - amcinonide ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.

References

Amcinonide Cream, Ointment (Sun Pharmaceutical Industries, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 17/09/2025.

Amcinonide. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 17/09/2025.

Amcinonide. UpToDate Lexidrug, AHFS DI (Adult and Pediatric) Online. American Society of Health-System Pharmacists, Inc. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 01/09/2025.

Amcinonide. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 01/09/2025.

Brayfield A, Cadart C (eds). Amcinonide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 01/09/2025.

Disclaimer: This information is independently developed by MIMS based on Amcinonide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2025 MIMS. All rights reserved. Powered by MIMS.com