Spiramycin: Uses, Dosage, Side Effects and More

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Intravenous
Toxoplasmosis, Cryptosporidiosis, Protozoal infections, Susceptible infections

Adult: 1.5 million units by slow infusion every 8 hr, may double the dose in severe infections.

Oral
Cryptosporidiosis, Protozoal infections, Susceptible infections, Toxoplasmosis

Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.
Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid.

What are the brands available for Spiramycin in Indonesia?

Spirasin

Other Known Brands

Ismacrol
Kalbiotic
Osmycin
Provamed
Rofacin
Rovadin
Rovamycine
Sorov
Spirabiotic
Spiradan
Spiramycin Indo Farma
Spiramycin OGB Dexa
Spiranter
Varoc
Vipram

Administration

May be taken with or without food.

Contraindications

Hypersensitivity.

Special Precautions

Hepatic impairment; pregnancy and lactation. Monitor liver function. History of arrhythmias or predisposition to QT interval prolongation.

Adverse Reactions

Nausea, vomiting, abdominal pain, diarrhoea; urticaria, pruritus, macular rashes. Transient paraesthesia may occur.
Potentially Fatal: Pseudomembranous colitis; anaphylaxis; neuromuscular blockade; ventricular arrhythmias, prolongation of QT interval.

Drug Interactions

Decreases carbidopa absorption and levodopa concentrations. Increased risk of ventricular arrhythmias when used with astemizole, cisapride and terfenadine. Risk of acute dystonia when used with fluphenazine.

Action

Description:
Mechanism of Action: Spiramycin is a macrolide antibacterial that inhibits protein synthesis by irreversibly binding to the 50S subunit of the ribosomal subunit thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth.
Pharmacokinetics:
Absorption: Incompletely absorbed from the GI tract (oral); peak plasma concentrations after 1.5-3 hr.
Distribution: Widely distributed into tissues, enters breast milk. Protein binding: 10-25%.
Metabolism: Metabolised hepatically to active metabolites.
Excretion: Via bile (as metabolites), via urine (10%); 5-8 hr (elimination half-life).

MIMS Class

Macrolides

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