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Indications and Dosage
Oral
Pain relief Adult: Up to 1.2 g daily in divided doses.
Elderly: Reduced doses. |
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Contraindications
Porphyria, hypersensitivity, peptic ulceration, moderate/severe renal impairment.
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Special Precautions
Patients with infection; haemorrhagic disorders; hypertension; cardiac function; asthma; diabetes mellitus; haemorrhoids; rectal irritation or bleeding; systemic lupus erythematosus; epilepsy, oedema; mental illness; parkinson's disease; polymyalgia rheumatica; temporal arthritis. Pregnancy and lactation. Monitor blood counts, kidney, liver and eye functions.
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Adverse Reactions
GI disturbances; CNS effects; hypersensitivity reactions; blood disorders; nephrotoxicity; haematuria; oedema; pancreatitis; toxic epidermal necrolysis; alveolitis; Stevens-Johnson syndrome; photosensitivity; pulmonary eosinophilia.
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Drug Interactions
Oral anticoagulants; antivirals; phenytoin; sulfonylurea antidiabetic; methotrexate; cardiac glycosides; ACE inhibitors; diuretics; β-blocker; other NSAIDs; lithium; ciclosporin; tacrolimus; moclobemide. Corticosteroids; antiplatelet drugs, biphosphonates, SSRIs and pentoxifylline increase GI bleeding risk. Avoid alcohol and tobacco.
Potentially Fatal: Increased risk of convulsions with quinolones. |
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Lab Interference
Thyroid function tests: Lowers serum thyroid hormone levels.
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Action
Description:
Mechanism of Action: It is an NSAID, which is an anthranilic acid derivative related to glafenine. |
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MIMS Class
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