Cefotaxime + Sulbactam: Uses, Dosage, Side Effects...

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Genitourinary infections, Lower respiratory tract infections

Adult: Mild to moderate infections: 1 g/0.5 g to 2 g/1 g of cefotaxime/sulbactam every 8-12 hrs. Moderate to severe infections: 1 g/0.5 g to 2 g/1 g of cefotaxime/sulbactam every 6-8 hrs. Max (sulbactam): 4 g.
Child: 100 mg/50 mg to 150 mg/75 mg of cefotaxime/sulbactam per kg/day in 3 divided doses. Life-threatening infections: Dose of cefotaxime may be increased up to 12 g/day.

Renal Impairment

Dose adjustment may be needed.

Contraindications

Hypersensitivity to cefotaxime, sulbactam or the combination.

Special Precautions

Previous hypersensitivity to penicillins or other drugs; patients with renal insufficiency; history of GI disease, esp colitis. Pregnancy and lactation.

Adverse Reactions

Local reactions including pain at the Inj site and phloebitis. Others: Skin rash, diarrhoea, nausea, vomiting and colitis.

Drug Interactions

Concomitant admin of cephalosporins and aminoglycoside antibiotics.

Action

Description:
Mechanism of Action: Cefotaxime is a bactericidal drug, which inhibits the bacterial wall synthesis of the actively dividing cells by binding to one or more penicillin-binding proteins. Sulbactam is a semisynthetic β-lactam sulphone, which inhibits β-lactamases of the Richmond types II, III, IV and V (plasmid or chromosomally mediated). This inhibition is reported to be both reversible and irreversible. It acts as a suicide inhibitor by forming a reversible inactive enzyme-sulbactam complex. This reversible acyl-intermediate may then revert to a more stable complex, which irreversibly inhibits the β-lactamase. Sulbactam is able to protect the activity of various β-lactam antibiotics by rendering β-lactamases inactive.

MIMS Class

Cephalosporins

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