Bulaquine: Uses, Dosage, Side Effects and More

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Treatment and prophylaxis of relapse of Plasmodium vivax malaria

Adult: 25 mg once daily for 7 days. To be used in comjunction with chloroquine.

Contraindications

Rheumatoid arthritis; systemic lupus erythematosus. Co-administration of drugs known to cause haemolysis.

Special Precautions

Exercise caution while administering bulaquine to patients suffering from G6PD deficiency. Pregnancy and lactation, children.

Drug Interactions

Specific studies with other drugs have not been undertaken except with chloroquine where it was concurrently used in the phase II/III clinical trials without any adverse effects.

Action

Description:
Mechanism of Action: Bulaquine is a new generation of 8-aminoqinoline derivative antimalarial used in managing P. vivax infection. It reportedly inhibits protein synthesis in protozoa and polymerization of amino acids by the plasmodia. When co-administered with chloroquine, malarial is treated witho significant relapse episodes. Compared to primaquine, it requires lesser treatment days and it has better tolerance profile in patients with G6PD (G6PDH) deficiency.

MIMS Class

Antimalarials

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