Bopindolol

2^nd and 3^rd ° AV block; sinus bradycardia; uncontrolled heart failure; bronchospasm or asthma, metabolic acidosis, severe peripheral arterial disease, phaeochromocytoma.

1^st ° AV block. May mask symptoms of hyperthyroidism and hypoglycaemia. May unmask myasthenia gravis. May aggravate psoriasis. Gradual withdrawal over 1-2 wk is advisable otherwise, it may result in angina, MI, ventricular arrhythmias and death. Pregnancy and lactation.

Bradycardia; hypotension; heart failure, heart block; bronchospasm; fatigue; coldness of extremities; pneumonitis; pulmonary and retroperitoneal fibrosis; pleurisy; CNS effects; myopathies; GI disturbances; skin rash; pruritus; reversible alopoecia; lupus-like syndrome; male impotence; sclerosing peritonitis; paraesthesias; peripheral neuropathy; muscle cramps; haematological reactions.

Drugs that cause hypotension; NSAIDs; other cardiac depressants; sotalol; digoxin; insulin and oral hypoglycaemics; sympathomimetics; ACE inhibitors; calcium-channel blockers, verapamil. Anaesthetics that cause myocardial depression (e.g. ether, cyclopropane, trichloroethylene).
Potentially Fatal: Increased risk of withdrawal HTN with clonidine. (Withdraw several days before slowly withdrawing clonidine).

Changes in blood concentrations of triglycerides, glucose and cholesterol.

Description:
Mechanism of Action: Bopindolol is a non-cardioselective β-blocker with some intrinsic sympathomimetic activity.

Beta-Blockers