Saridon

Composition: 250 mg paracetamol, 150 mg propyphenazone and 50 mg caffeine.

Properties and effects: Saridon is a combination of analgesic and antipyretic substances with a small quantity of caffeine. Its components are carefully balanced to give rapid and effective relief of pain which lasts for several hours.

Headache and various pain, e.g. toothache, menstrual pain, migraine, neuralgia, neuritis, post-operative and rheumatic pain; febrile illnesses (influenza, etc.).

Single dose: adults: l-2 tablets.
This single dose may be taken three times in 24 hours. The tablets may be taken whole and washed down with a large volume of water or other suitable liquid.
Analgesics should not be taken for prolonged periods of time or in high doses without consulting a doctor. Saridon should be used at the lowest effective dose for shortest possible time.

Saridon is contraindicated: i) in patients with severe heart failure; and ii) for the treatment of peri-operative pain in the setting of coronary artery bypass graft surgery.
History of gastrointestinal bleeding or perforation, related to previous Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) therapy; active, or history of recurrent peptic ulcer/haemorrhage.
In the presence of severe disorders of kidney function, congenital deficiency of glucose-6-phosphate-dehydrogenase (hemolytic anemia), acute hepatic porphyria and evidence of allergic sensitivity to the active ingredients of Saridon.
Saridon should not be used in infants and children.
The established medical principle of prescribing medicaments in early pregnancy only when absolutely indicated should be borne in mind.

Cardiovascular Risk: NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk.
Gastrointestinal Risk: NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events.
Renal Effects: Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of a NSAID may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, and the elderly. Discontinuation of NSAID therapy is usually followed by recovery to the pretreatment state.
Advanced Renal Disease: No information is available from controlled clinical studies regarding the use of Saridon in patients with advanced renal disease. Therefore, treatment with Saridon is not recommended in these patients with advanced renal disease. If therapy must be initiated, close monitoring of the patient's renal function is advisable.

Saridon is usually well tolerated. In some cases occasional allergic skin reactions have been observed (skin rash, urticaria). Do not exceed the stated dose. Inappropriate use of this medicine has the potential to cause liver toxicity or severe liver damage. Do not take with any other drugs containing paracetamol unless advised by a healthcare professional.

With Saridon, as with other analgesics, patients should avoid taking alcohol while under treatment, since the individual response cannot be foreseen.

Analgesics (Non-Opioid) & Antipyretics

N02BE51 - paracetamol, combinations excl. psycholeptics ; Belongs to the class of anilide preparations. Used to relieve pain and fever.

NP