Use at the lowest effective dose for shortest possible time. May cause an increased risk of serious CV thrombotic events, MI, & stroke; serious GI adverse events including bleeding, ulceration, & stomach or intestine perforation. Long-term NSAID administration may result in renal papillary necrosis & other renal injury; risk of renal toxicity in patients whose renal prostaglandins have a compensatory role in the maintenance of renal perfusion. Not recommended in patients w/ advanced renal disease. Established medical principle of prescribing medicaments in early pregnancy only when absolutely indicated should be borne in mind.