Mycamine

Treatment of adult & ped patients ≥4 mth w/ candidemia, acute disseminated candidiasis, candida peritonitis & abscesses; esophageal candidiasis. Prophylaxis of Candida infections in adult & ped patients ≥4 mth undergoing hematopoietic stem cell transplantation (HSCT).

Administer by IV infusion over 1 hr. Treatment of candidemia, acute disseminated candidiasis, candida peritonitis & abscesses Adult 100 mg once daily. Ped patient 2 mg/kg once daily (max 100 mg daily). Treatment of esophageal candidiasis Adult 150 mg once daily. Ped patient >30 kg 2.5 mg/kg once daily (max 150 mg daily), ≤30 kg 3 mg/kg once daily. Prophylaxis of Candida infections in HSCT recipients Adult 50 mg once daily. Ped patient 1 mg/kg once daily (max 50 mg daily).

Hypersensitivity to micafungin or other echinocandins.

Discontinue in cases of serious hypersensitivity reactions. Monitor for evidence of worsening hepatic & renal function & hemolysis or hemolytic anemia during therapy. Has not been adequately studied in patients w/ endocarditis, osteomyelitis & meningitis due to Candida infections. Efficacy against infections caused by fungi other than Candida has not been established. Not for IV bolus inj. Use during pregnancy only if potential benefit justifies potential risk to fetus. Exercise caution when administering to nursing woman. Safety & effectiveness in ped patients <4 mth have not been established.

Diarrhea, nausea, vomiting. Adult (candidemia & other Candida infections): Hypoglycemia, hypernatremia, hyperkalemia; pyrexia; increased blood alkaline phosphatase; atrial fibrillation. Adult (esophageal candidiasis): Pyrexia; headache; phlebitis; rash. Adult (prophylaxis of Candida infections in HSCT recipients): Abdominal pain; neutropenia, thrombocytopenia; rash; headache; insomnia, anxiety; tachycardia. Ped patients: Abdominal pain/distension; pyrexia, infusion-related reaction; pruritus, rash, utricaria; epistaxis; thrombocytopenia, neutropenia, anemia, febrile neutropenia; increased ALT, decreased urine output; tachycardia; hematuria; anxiety.

Increased AUC of sirolimus. Increased AUC & C_max of nifedipine; itraconazole.

Antifungals

J02AX05 - micafungin ; Belongs to the class of other systemic antimycotics.

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