Methadone Pliva Warnings

Endeavours should be made not to increase the dose above that recommended, and to administer Methadone only for a limited period (except in cases of malignant processes), as tolerance and toxicomania are likely to develop.
Limit dosages and durations to the minimum required.
Follow patients for signs and symptoms of respiratory depression and sedation.
Accidental exposure: Accidental consumption of even one dose of Methadone Tablet, especially by children, can result in a fatal overdose of methadone.
Risks from concomitant use with benzodiazepines or other CNS depressants: Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.
Reserve concomitant prescribing of Methadone Tablet and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate.
Hypoglycaemia: Hypoglycaemia has been observed in the context of methadone overdose or dose escalation. Regular monitoring of blood sugar is recommended during dose escalation.
Hypoglycaemia is an undesirable effect with unknown frequency.