Methadone Tablets is indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate, for example, severe pain when other drugs provide no relief, i.e. in carcinoma and other malignant diseases, in burns, infarct of myocardium, neuritis and severe neuralgia, biliary and renal colics, vesical tenesmus, post-operative and post-traumatic pain.