Mepyramine: Uses, Dosage, Side Effects and More

This information is not country-specific. Please refer to the Hong Kong prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Skin irritation

Adult: For symptomatic relief of skin irritation associated with insect bites and stings, and nettle rash: As 2% w/w cream: Apply directly onto the affected area(s) 2-3 times daily for up to 3 days.
Child: >2 years Same as adult dose.

Contraindications

Application to eczematous skin conditions, sunburned skin, or skin with extensively broken, cut, or grazed surfaces and on large areas of the skin.

Special Precautions

Children. Pregnancy and lactation.

Adverse Reactions

Significant: Rarely, skin sensitisation.
Skin and subcutaneous tissue disorders: Allergic skin reaction.

Patient Counseling Information

This drug may occasionally cause somnolence and mild disorientation, if affected, do not drive or operate machinery.

Action

Description:
Mechanism of Action: Mepyramine, an ethylenediamine derivative, is an antihistamine with antipruritic, sedative, and local analgesic properties. It blocks the binding of histamine on H₁-receptor sites thus inhibiting the effect of histamine in the body.
Synonym(s): Pyrilamine.

Chemical Structure

Storage

Store below 25°C.

MIMS Class

Topical Antihistamines/Antipruritics

ATC Classification

D04AA02 - mepyramine ; Belongs to the class of topical antihistamines used in the treatment of pruritus.

References

Anon. Mepyramine [Pyrilamine] (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/03/2024.

Anthisan Cream (Phoenix Labs Unlimited Company). MHRA. https://products.mhra.gov.uk. Accessed 08/03/2024.

Buckingham R (ed). Mepyramine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/03/2024.

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