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Surgery should not be delayed in patients requiring urgent amputation (e.g. in infected gangrene).
Patients should be strongly advised to stop smoking.
Iloprost elimination is reduced in patients with hepatic dysfunction and in patients with renal failure requiring dialysis.
In patients with low blood pressure care should be taken to avoid further hypotension and patients with significant heart disease should be closely monitored.
The possibility of orthostatic hypotension should be borne in mind in patients getting up from the lying to an upright position after the end of administration.
For patients with a cerebrovascular event [e.g. transient ischemic attack, stroke] within the last 3 months a careful benefit-risk evaluation should be undertaken.
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