Cinchocaine: Uses, Dosage, Side Effects and More

This information is not country-specific. Please refer to the Hong Kong prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Anorectal disorders, Haemorrhoids

Adult: For the temporary relief of pain and itching: As 1% ointment: Apply to the anal area 3-4 times daily.
Child: For the temporary relief of pain and itching: As 1% ointment: ≥12 years Same as adult dose.

What are the brands available for Cinchocaine in Hong Kong?

Cinchocaine Hydrochloride Synco

Special Precautions

Patient with G6PD deficiency, congenital or idiopathic methaemoglobinaemia, cardiac or pulmonary compromise, exposure to oxidising agents or their metabolites. Children. Pregnancy and lactation.

Adverse Reactions

Significant: Methaemoglobinaemia.
Skin and subcutaneous tissue disorders: Acute generalised exanthematous pustulosis, allergic dermatitis.

Patient Counseling Information

Discontinue use if bleeding occurs or if anorectal condition worsens or does not improve within 7 days. Do not apply into the rectum using fingers or any mechanical device or applicator.

Action

Description:
Mechanism of Action: Cinchocaine is an amide-type local anaesthetic. It inhibits the initiation and conduction of nerve impulses by reducing sodium ion permeability of the neuronal membrane, thereby preventing depolarisation with resultant conduction blockade.
Synonym(s): Dibucaine.
Onset: Within 15 minutes.
Duration: 2-4 hours.
Pharmacokinetics:
Absorption: Well absorbed through the mucous membranes and excoriated skin; poorly absorbed through intact skin.

Chemical Structure

Storage

Store between 20-25°C.

MIMS Class

Anaesthetics - Local & General

ATC Classification

C05AD04 - cinchocaine ; Belongs to the class of local anesthetics. Used in the topical treatment of hemorrhoids and anal fissures.
D04AB02 - cinchocaine ; Belongs to the class of topical anesthetics used in the treatment of pruritus.

References

Brayfield A, Cadart C (eds). Cinchocaine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/08/2025.

Cinchocaine [Dibucaine]. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 05/08/2025.

Dibucaine Topical Anesthetic 1% Hemorrhoidal Ointment (Rugby Laboratories Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 05/08/2025.

Dibucaine. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 05/08/2025.

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