Azithromycin 250 - 1 A Pharma

Acute bacterial sinusitis; acute bacterial otitis media; pharyngitis/tonsillitis; acute exacerbation of chronic bronchitis; mild to moderately severe community-acquired pneumonia; skin & soft tissue infections; uncomplicated Chlamydia trachomatis urethritis & cervicitis.

Adult 500 mg/day for 3 consecutive days. Uncomplicated Chlamydia trachomatis urethritis & cervicitis 1,000 mg as single dose.

May be taken with or without food: May be taken w/ meals to reduce GI discomfort.

Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotics.

Reports of serious allergic reactions including angioneurotic oedema & anaphylaxis, acute generalised exanthematous pustulosis & DRESS; Clostridium difficile-associated diarrhea; exacerbations of myasthenia gravis symptoms & new onset of myasthenia syndrome. Risk of QT interval prolongation. Stop treatment if liver dysfunction has emerged. Observe for signs of superinfection. No efficacy data on prevention of acute rheumatic fever. Do not co-administer w/ ergot derivatives. Contains sulfur dioxide. Patients w/ rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine. Patients w/ significant hepatic disease; severe renal impairment (GFR <10 mL/min). Pregnancy & lactation.

Diarrhoea, abdominal pain, nausea, flatulence. Anorexia; dizziness, headache, paraesthesia, dysgeusia; visual impairment; deafness; vomiting, dyspepsia; rash, pruritus; arthralgia; fatigue; decreased lymphocyte count, increased eosinophil count, decreased blood bicarbonate.

Reduced peak serum conc w/ antacids. Increased serum levels of P-gp substrates eg, digoxin & colchicine. Increased conc of phosphorylated zidovudine. Theoretical possibility of ergotism w/ ergot derivatives. Post-marketing reports of potentiated anticoagulation subsequent to co-administration of azithromycin & coumarin-type oral anticoagulants. Elevated C_max & AUC_0-5 of ciclosporin. Increased conc w/ nelfinavir.

Macrolides

J01FA10 - azithromycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.

A